张雨萌

姓名：张雨萌

性别：女

籍贯：辽宁盘锦

政治面貌：中共党员

联系邮箱：zymshane@126.com

研究方向：

1.药品质量控制及分析新技术开发

2.中药物质基础及药物代谢研究

3.基于单细胞多组学的药物治疗机制研究

职称：讲师

学习/工作经历：

2012年毕业于南京师范大学食品质量与安全专业，获学士学位；同年攻读南京师范大学食品工程硕士，2014年获食品工程硕士学位；2014-2019年就职于大连市食品检验所；2019年-2022年攻读沈阳药科大学药物分析学博士，2022年6月获药物分析学博士学位；2022年8月至今就职于沈阳药科大学药物分析教研室。

所获荣誉：辽宁省食品安全检验检测技能竞赛二等奖

大连市食品安全检验检测技能竞赛二等奖

科研成果：

科研项目：

1.单细胞多组学解析肝纤维化氨代谢微环境变化，辽宁省教育厅（自主选题项目），项目编号LJ212410163031，主持。

2.苯磺酸氨氯地平片、一清片检测新方法开发研究（专利开发），校企合作项目，主持。

论文发表：

1.Zhang YM^#, Zhao M^#, Jiang X, Qiao QY, Liu TT, Zhao CJ^*, Wang M^*. Comprehensive analysis of fecal microbiome and metabolomics in hepatic fibrosis rats reveal hepatoprotective effects of Yinchen Wuling Powder from the host-microbial metabolic axis. Frontiers in Pharmacology, 2021, 12: 713197. (IF：5.988)

2.Zhang YM, Liu TT, Zhao YH, Zhao CJ^*, Zhao M^*. Deciphering the enigma between low bioavailability and high anti-hepatic fibrosis efficacy of Yinchen Wuling powder based on drug metabolism and network pharmacology. Journal of Ethnopharmacology, 2024, 321: 117538. (IF：4.8)

3.Zhang YM^#, Zhao M^#, Liu YY, Liu TT, Zhao CJ^*, Wang M^*. Investigation of the therapeutic effect of Yinchen Wuling Powder on CCl₄-induced hepatic fibrosis in rats by ¹H NMR and MS-based metabolomics analysis. Journal of Pharmaceutical and Biomedical Analysis, 2021, 200: 114073. (IF：3.571)

4.Zhang YM^#, Zhao M^#, Liu TT, Zhu WJ, Zhao CJ^*, Wang M^*. Rapid characterization of the chemical constituents of Yinchen Wuling Powder by UPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2021, 198: 114022. (IF：3.571)

5.Yuan B^#, Zhang YM^#, Man XT, Zhao CJ^*, Zhao M^*. Magnetic ligand fishing protocol combined with HPLC-FT-ICR-MS for screening potential α-Glucosidase inhibitors from UCG and in silico analysis. Arabian Journal of Chemistry, 2024, 17(9): 105899. (IF：5.3)

6.Weng L^#, Zhao M^#, Zhang YM^#, Liu XY, Wang ZY, Xu RX, Zhang JY, Wang YJ, Wang M^*, Zhao CJ^*. American ginseng vesicles loaded hyaluronic acid hydrogel for ulcerative colitis. International Journal of Biological Macromolecules, 2025, 288: 138565. (IF：7.7)

7.Zhao YH^#, Zhao M^#, Wang ZY, Zhao CJ^*, Zhang YM^*, Wang M^*. Danggui Shaoyao San: Chemical characterization and inhibition of oxidative stress and inflammation to treat CCl₄-induced hepatic fibrosis. Journal of Ethnopharmacology, 2024, 318: 116870. (IF：4.8)

8.Li ZY^#, Zhao M^#, Wang ZY, Ma LZ, Pan X, Jin T, Fu ZX, Yuan B, Zhao CJ^*, Zhang YM^*. Combining metabolomics with network pharmacology to reveal the therapeutic mechanism of Dingchuan Decoction in rats with OVA-induced allergic asthma. Journal of Pharmaceutical and Biomedical Analysis, 2024, 247: 116265. (IF：3.1)

9.Fu ZX^#, Zhang YM^#, Jin T, Wang ZY, Zhao CJ^*, Zhao M^*. A comprehensive quality evaluation strategy of Shensong Yangxin capsules based on qualitative, fingerprint and quantitative analyses. Biomedical Chromatography, 2024, 38(4): e5832. (IF：1.8)

10.Pan X^#, Zhang YM^#, Qiao YY, Cao QY, Wei LX, Zhao M^*. Investigation of the therapeutic effect of Hedan tablets on high-fat diet-induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing. Biomedical Chromatography, 2024, 38(5): e5848. (IF：1.8)

11.Wang ZY^#, Zhang YM^#, Fu ZX, Jin T, Zhao CJ^*, Zhao M^*. A comprehensive strategy for quality evaluation of Changan powder by fingerprinting combined with rapid qualitative and quantitative multi-ingredients profiling. Phytochemical Analysis, 2024, 35(4): 840-859. (IF：3.0)

专利：

1.万韬，王洪，李冶，姚洪涛，张子枭，陈光，张雨萌。一种盐酸达克罗宁的合成方法。发明专利，专利号：ZL 2024 1 0390457.1。

2.万韬，王洪，李冶，姚洪涛，陈光，张雨萌。一种可比落的合成工艺。发明专利，专利号：ZL 2024 1 0941737.7。

3.万韬，李冶，张雨萌。一种旋转蒸发仪。实用新型专利，专利号：ZL 2024 2 1645003.6。

4.黄彦辉，张雨萌，万韬，李巍，宋宇，王思雨。一种用于药物制造的离心机。实用新型专利，专利号：ZL 2024 2 0053786.2。

5.李巍，张雨萌，万韬，黄彦辉，宋宇，王思雨。一种具备防堵功能的废水接受罐。实用新型专利，专利号：ZL 2024 2 0054764.8。

指导研究生情况：无

其他：2024、2025年度辽宁省企业科技特派员