李会

姓名：李会

性别：女

籍贯：河北衡水

政治面貌：群众

联系邮箱：lihui_633@163.com; 101040126@syphu.edu.cn

研究方向：药物代谢,药物毒理及安全用药；代谢酶的功能和调控

学习/工作经历：

2010.09 – 2014.06 药学（理科基地班），本科

沈阳药科大学

2014.09 – 2019.06 药物分析学，博士

方向: 药物代谢致肝毒性机制研究

导师: 郑江教授；彭璎教授

沈阳药科大学

2019.09 –2024.09 博士后研究员

药学院药理毒理研究室

方向：代谢酶的功能和调控；药物代谢动力学

合作导师: Prof. Xinxin Ding 和 Prof. Qing-Yu Zhang

亚利桑那大学（The University of Arizona, USA）

2025.01-至今 教师，沈阳药科大学药学院药物分析教研室

所获荣誉：

1. Awardee of “First Place Prize in the Division for Toxicology Postdoc Poster Competition” at the 2023 ASPET Annual Meeting, St. Louis, Missouri, USA (2023) “Differential Induction of Microsomal and Soluble Epoxide Hydrolases by Arsenic in Drinking Water.”

2. Awardee of a Travel Award at the 2023 ASPET Annual Meeting, St. Louis, Missouri, USA (2023)

3. 沈阳药科大学校级优秀毕业生 (2019)

4. 第十二届全国药物和化学异物质代谢学术会议 “青年优秀论文奖” 一等奖， 中国药理学会药物代谢专业委员会举办，郑州 (2018) “Structure-Toxicity Relationship Study of Nitrofurantoin by Structural Dissection”.

5. 第六届国际药物代谢学会亚太地区会议 (APISSX) “Young Scientist Awards for best poster presentation” 二等奖，国际药物代谢和中国药理学会药物代谢专业委员会举办，杭州 (2018) “Structure-Toxicity Relationship Study of Nitrofurantoin Metabolism and Its Hepatic Cytotoxicity”.

科研成果：

1. Li, H., Fan, X., Ding, and Zhang, Q. Y. Tissue-, region-, and gene-specific induction of microsomal epoxide hydrolase expression and activity in the mouse intestine by arsenic in drinking water. Drug Metab Dispos. 2024 52 (7) 681-689.

2. Mao, X., Li, H., and Zheng, J. Effects of xenobiotics on CYP1 enzyme-mediated biotransformation and bioactivation of estradiol. Drug Metab Rev. 2023 55(1-2), 1-49. （通讯作者）

3. Li, H., Fan, X., Wu, X., Han, W., Amistadi, M.K., Liu, P., Zhang, D., Chorover, J., Ding, X. and Zhang, Q.Y. Differential Effects of Arsenic in Drinking Water on Mouse Hepatic and Intestinal Heme Oxygenase-1 Expression. Antioxidants. 2022 11(9), 1835.

4. Li, H., Peng, Y., Zheng, J. Dioscorea bulbifera L.-induced hepatotoxicity and involvement of metabolic activation of furanoterpenoids. Drug Metab Rev. 2020 52(4), 568-584.

5. Li, H., Zhang, Z., Yang, X., Mao, X., Wang, Y., Wang, J., Peng, Y., Zheng, J. Electron deficiency of nitro group determines hepatic cytotoxicity of nitrofurantoin. Chem Res Toxicol. 2019 32(4), 681-690.