李坤杰

姓名：李坤杰

性别：女

籍贯：辽宁省本溪市

政治面貌：中共党员

联系邮箱：likunjie_lkj@126.com

研究方向：药物代谢

职称：讲师

学习/工作经历：

2005年9月-2009年7月 沈阳药科大学 基础药学理科基地班 本科

2009年9月-2013年7月 沈阳药科大学 药物分析专业 硕博连读

2014年9月-至今 沈阳药科大学药学院 分析化学教研室 讲师

科研成果：

[1] Jiaxin Yao; Xu Jiang; Qiao Liu; Xuemei Yuan; Tiantian Feng; Kunjie Li*;Longshan Zhao**; An available strategy based on accurate mass by ultra highperformance liquid chromatography coupled to Fourier transform ion cyclotronresonance mass spectrometry technology to characterization of metabolic profile ofpalbociclib in rat urine, feces and bile, Journal of Chromatography B, 2019, 1124:37-46.

[2] Kunjie Li; Xu Jiang; Zhili Xiong; Feng Qin; Longshan Zhao*; The tissuedistribution and excretion study of mosapride and its active des-p-fluorobenzyl and4’-N-oxide metabolites in rats by ultra-high performance liquidchromatography-tandem mass spectrometry method, Xenobiotica, 2019, 49: 202-211.

[3] Jiaxin Yao†; Kunjie Li†; Yufeng Song; Zhonggui He; Zheng Liu; LongshanZhao*; Shaojie Wang*; The synthesis and biological evaluation of a new bioactivemetabolite of mosapride as a potential gastroprokinetic agent, Future MedicinalChemistry, 2019, 11: 21-32. （†Co-first author）

[4] Kunjie Li; Xingjie Guo; Feng Qin; Zhili Xiong; Longshan Zhao*; Jia Yu*;Identification of the cytochrome P450 enzymes involved in the oxidative metabolismof trantinterol using ultra high-performance liquid chromatography coupled withtandem mass spectrometry, RSC Advances, 2018, 8, 34764-34772.

[5] Kunjie Li; Yanjuan Wang; Lili Zhang; Feng Qin; Xingjie Guo**; Famei Li*;Simultaneous determination of trantinterol and its metabolites in rat urine and fecesby liquid chromatography–tandem mass spectrometry, Journal of Chromatography B,2013, 934: 89-96.

[6] Kunjie Li; Feng Qin*; Lijuan Jing; Famei Li; Xingjie Guo*; In vivo and in vitrometabolism of a novel β2-adrenoceptor agonist, trantinterol: Metabolites isolation andidentification by LC-MS/MS and NMR, Analytical and Bioanalytical Chemistry,2013, 405: 2619–2634.